Here's my experience so far on a Windows 10 computer:
It works well with the Audient iD 14 USB interface. I just had to learn to use the Audient software, which controls the recording levels after the preamp gain has been dialed in. I recorded a track, did an overdub, then applied reverb to both tracks. Everything sounded fine.
I tried recording with my Zoom G5n guitar multi-effect plugged into my computer via USB, using Zoom's latest ASIO. MixPad kept crashing. Obviously, the two don't get along. So I will be recording electric guitar with the Zoom analog outs going into the Audient.